![]() ![]() In this issue, Hard and colleagues present a pharmacometric study of aripiprazole to characterize aripiprazole disposition following intramuscular (IM) administration of a nano-crystalline milled dispersion of aripiprazole lauroxil (AL NCD) and AL and oral administration of aripiprazole, and to explore the feasibility of a 1-day initiation regimen using AL NCD plus oral aripiprazole alternative to the 21-day initiation regimen of AL alone, and to inform strategies to manage missed doses of AL under different treatment scenarios. Failure in the management of missed doses under various scenarios during treatment with antipsychotic medications might lead to a relapse of schizophrenia. ![]() Systems pharmacology and pharmacometric modeling and simulation have become increasingly important in accelerating drug development and regulatory approval nevertheless, their use in precision pharmacotherapy and management of missed doses remain scarce. ![]()
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